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Elastase inhibitors as potential therapies for ELANE ‐associated neutropenia
Author(s) -
Makaryan Vahagn,
Kelley Merideth L.,
Fletcher Breanna,
Bolyard Audrey Anna,
Aprikyan A. Andrew,
Dale David C.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5a1016-445r
Subject(s) - biology , neutrophil elastase , neutropenia , elastase , neutrophil extracellular traps , immunology , induced pluripotent stem cell , cancer research , congenital neutropenia , enzyme , inflammation , chemotherapy , biochemistry , gene , genetics , embryonic stem cell
Inhibitors of NE improve survival and differentiation of iPSC and HL60 cells expressing mutant NE.