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Elevated interferon‐γ–induced protein 10 and its receptor CXCR3 impair NK cell function during HIV infection
Author(s) -
Wang Zhuo,
Wu Tong,
Ma Meichen,
Zhang Zining,
Fu Yajing,
Liu Jing,
Xu Junjie,
Ding Haibo,
Han Xiaoxu,
Chu Zhenxing,
Wu Yuntao,
Shang Hong,
Jiang Yongjun
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.5a1016-444r
Subject(s) - cxcr3 , biology , immunology , interleukin 21 , interferon , interleukin 12 , chemokine receptor , chemokine , cxcl10 , cancer research , immune system , t cell , cytotoxic t cell , in vitro , biochemistry
IP‐10 negatively regulates NK cell function during HIV infection, making its blockage a potential novel immunotherapy target to increase NK‐mediated clearance of HIV.