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A Pseudomonas aeruginosa hepta‐acylated lipid A variant associated with cystic fibrosis selectively activates human neutrophils
Author(s) -
SenGupta Shuvasree,
Hittle Lauren E.,
Ernst Robert K.,
Uriarte Silvia M.,
Mitchell Thomas C.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4vma0316-101r
Subject(s) - cystic fibrosis , pseudomonas aeruginosa , biology , microbiology and biotechnology , immunology , bacteria , genetics
Lipid A produced by P. aeruginosa only in the late stages of CF stimulates IL‐8 production and survival, but not granule exocytosis by human neutrophils.