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Elevated postinjury thrombospondin 1–CD47 triggering aids differentiation of patients' defective inflammatory CD1a + dendritic cells
Author(s) -
Bandyopadhyay Gautam,
Bandyopadhyay Sanjukta,
Bankey Paul E.,
MillerGraziano Carol L.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4ma0214-077r
Subject(s) - cellular differentiation , biology , immunology , dendritic cell , microbiology and biotechnology , immune system , biochemistry , gene
Post‐injury differentiation of dysfunctional CD1a + monocytederived dendritic cells can result from elevated thrombospondin‐1, triggering CD47, and increasing inhibitory SHP‐1 activation and immunodepression.