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Attrition of memory CD8 T cells during sepsis requires LFA‐1
Author(s) -
Serbanescu Mara A.,
Ramonell Kimberly M.,
Hadley Annette,
Margoles Lindsay M.,
Mittal Rohit,
Lyons John D.,
Liang Zhe,
Coopersmith Craig M.,
Ford Mandy L.,
McConnell Kevin W.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a1215-563rr
Subject(s) - sepsis , cd8 , phenotype , cytotoxic t cell , immunology , biology , t cell , cytokine , antigen , immune system , genetics , in vitro , gene
Sepsis activates memory CD8 T cells independent of cognate antigen, and likely through cytokine‐mediated signaling; the loss of unactivated cells requires direct TCR:MHC interactions.