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Control of influenza infection is impaired by diminished interferon‐γ secretion by CD4 T cells in the lungs of toddler mice
Author(s) -
Verhoeven David,
Perry Sheldon,
Pryharski Karin
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a1014-497rr
Subject(s) - biology , interferon , immunology , toddler , virus , antibody , influenza a virus , t cell , lung , virology , immune system , medicine , psychology , developmental psychology
Diminished IFN‐γ in the lungs of 21‐ day‐young (toddler) mice throughout infection corresponds to intrinsic rather than extrinsic CD4 T cell limitations in IFN‐γ transcription, indicating a limited CD4 T cell response in toddler age.