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Limited specificity of IRF3 and ISGF3 in the transcriptional innate‐immune response to double‐stranded RNA
Author(s) -
Ourthiague Diana R.,
Birnbaum Harry,
Ortenlöf Niklas,
Vargas Jesse D.,
Wollman Roy,
Hoffmann Alexander
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a1014-483rr
Subject(s) - irf3 , innate immune system , biology , transcription factor , interferon regulatory factors , rna silencing , transcriptome , microbiology and biotechnology , immune system , pattern recognition receptor , gene , genetics , gene expression , rna , rna interference
Immune response regulators IRF3 and ISGF3 bind to and activate an overlapping set of target genes, but IRF3 specificity is critical in activating IFNβ.