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HIV‐1 decreases Nrf2/ARE activity and phagocytic function in alveolar macrophages
Author(s) -
Staitieh Bashar S.,
Ding Lingmei,
Neveu Wendy A.,
Spearman Paul,
Guidot David M.,
Fan Xian
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0616-282rr
Subject(s) - gclc , biology , immune system , gclm , immunology , oxidative stress , alveolar macrophage , macrophage , transgene , microbiology and biotechnology , virology , downregulation and upregulation , in vitro , endocrinology , gene , biochemistry
Antioxidant defenses in alveolar macrophages are impaired by HIV‐related viral proteins, which can be reversed by supplemental treatments that enhance the Nrf2‐ARE.