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Neutrophil extracellular traps release induced by Leishmania : role of PI3Kγ, ERK, PI3Kσ, PKC, and [Ca 2+ ]
Author(s) -
DeSouzaVieira Thiago,
GuimarãesCosta Anderson,
Rochael Natalia C.,
Lira Maria N.,
Nascimento Michelle T.,
LimaGomez Phillipe de Souza,
Mariante Rafael M.,
Persechini Pedro M.,
Saraiva Elvira M.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0615-261rr
Subject(s) - neutrophil extracellular traps , biology , microbiology and biotechnology , extracellular , leishmania , intracellular , pi3k/akt/mtor pathway , reactive oxygen species , programmed cell death , mapk/erk pathway , signal transduction , kinase , biochemistry , immunology , inflammation , parasite hosting , apoptosis , world wide web , computer science
PI3Kγ‐mediated activation of ERK regulates oxidative burst‐dependent netosis, while PI3Kσ and calcium are key signals for netosis independent of oxidative burst induced by Leishmania .