Premium
Brucella abortus down‐regulates MHC class II by the IL‐6‐dependent inhibition of CIITA through the downmodulation of IFN regulatory factor‐1 (IRF‐1)
Author(s) -
Velásquez Lis N.,
Milillo M. Ayelén,
Delpino M. Victoria,
Trotta Aldana,
Fernández Pablo,
Pozner Roberto G.,
Lang Roland,
Balboa Luciana,
Giambartolomei Guillermo H.,
Barrionuevo Paula
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0416-196r
Subject(s) - ciita , biology , mhc class ii , microbiology and biotechnology , transcription factor , major histocompatibility complex , mhc class i , irf1 , immunology , antigen , genetics , gene
Molecular mechanisms employed by B. abortus to inhibit MHC‐II surface expression, in order to evade host immunity and establish a chronic infection.