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Hepatic CD206‐positive macrophages express amphiregulin to promote the immunosuppressive activity of regulatory T cells in HBV infection
Author(s) -
Dai Kai,
Huang Ling,
Sun Xiaomei,
Yang Lihua,
Gong Zuojiong
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0415-152r
Subject(s) - amphiregulin , biology , hepatitis b virus , macrophage , immunology , immune system , adoptive cell transfer , acquired immune system , t cell , regulatory t cell , cd8 , virology , virus , il 2 receptor , epidermal growth factor receptor , receptor , biochemistry , in vitro
Activation of mTORC1 signaling in regulatory T cells by macrophage‐derived amphiregulin contributes to suppression of CD8 + T cell‐mediated anti‐HBV immunity.