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Elk‐3 is a KLF4‐regulated gene that modulates the phagocytosis of bacteria by macrophages
Author(s) -
Tsoyi Konstantin,
Geldart Adriana M.,
Christou Helen,
Liu Xiaoli,
Chung Su Wol,
Perrella Mark A.
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.4a0214-087r
Subject(s) - biology , repressor , phagocytosis , microbiology and biotechnology , klf4 , promoter , transcription factor , transcriptional regulation , escherichia coli , regulation of gene expression , gene , gene expression , genetics , sox2
Down‐regulation of Elk‐3 by bacterial LPS, in part through the transcriptional repressor KLF4, allows for up‐regulation of HO‐1 and a compensatory phagocytic response in macrophages.