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Targeting ADAM17 in leukocytes increases neutrophil recruitment and reduces bacterial spread during polymicrobial sepsis
Author(s) -
Mishra Hemant K,
Johnson Timothy J.,
Seelig Davis M.,
Walcheck Bruce
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3vmab1115-496rr
Subject(s) - disintegrin , metalloproteinase , conditional gene knockout , biology , sepsis , immunology , knockout mouse , gene knockout , inflammation , tumor necrosis factor alpha , proinflammatory cytokine , microbiology and biotechnology , receptor , matrix metalloproteinase , phenotype , gene , biochemistry
ADAM17 activity in leukocytes during sepsis tips the balance between efficient and impaired neutrophil migration into sites of infection.