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Rapid externalization of 27‐kDa heat shock protein (HSP27) and atypical cell death in neutrophils treated with the sphingolipid analog drug FTY720
Author(s) -
SkrzeczyńskaMoncznik Joanna,
Bzowska Małgorzata,
Nogieć Anna,
Sroka Agnieszka,
Zarebski Mirosław,
Vallières Luc,
Guzik Krzysztof
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3vma1114-522rr
Subject(s) - biology , microbiology and biotechnology , fingolimod , heat shock protein , programmed cell death , protein kinase a , geldanamycin , protein kinase c , kinase , apoptosis , hsp90 , biochemistry , immunology , multiple sclerosis , gene
FTY720 induces rapid cell surface expression of HSP27, which coincides with atypical cell death sensitive to inhibitors of apoptosis, necroptosis, or NADPH oxidase.