Premium
TLR9 expression and secretion of LIF by prostate cancer cells stimulates accumulation and activity of polymorphonuclear MDSCs
Author(s) -
Won Haejung,
Moreira Dayson,
Gao Chan,
Duttagupta Priyanka,
Zhao Xingli,
Manuel Edwin,
Diamond Don,
Yuan YateChing,
Liu Zheng,
Jones Jeremy,
D’Apuzzo Massimo,
Pal Sumanta,
Kortylewski Marcin
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ma1016-451rr
Subject(s) - prostate cancer , cancer research , tlr9 , biology , cancer cell , stat3 , carcinogenesis , immune system , cytokine , tumor microenvironment , cancer , tramp , immunology , signal transduction , gene expression , microbiology and biotechnology , biochemistry , genetics , gene , dna methylation
TLR9 upregulation in prostate cancer cells results in the LIF‐mediated recruitment and increased tolerogenic activity of polymorphonuclear myeloid‐derived suppressor cells.