SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome | Zendy

Vachharajani Vidula T. | Zendy; Liu Tiefu | Zendy; Brown Candice M. | Zendy; Wang Xianfeng | Zendy; Buechler Nancy L. | Zendy; Wells Jonathan David | Zendy; Yoza Barbara K. | Zendy; McCall Charles E. | Zendy

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SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome

Author(s) -

Vachharajani Vidula T.,

Liu Tiefu,

Brown Candice M.,

Wang Xianfeng,

Buechler Nancy L.,

Wells Jonathan David,

Yoza Barbara K.,

McCall Charles E.

Publication year - 2014

Publication title -

journal of leukocyte biology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.819

H-Index - 191

eISSN - 1938-3673

pISSN - 0741-5400

DOI - 10.1189/jlb.3ma0114-034rr

Subject(s) - sepsis , biology , immunology , inflammation , ex vivo , nad+ kinase , spleen , proinflammatory cytokine , acute phase protein , systemic inflammation , cancer research , in vivo , biochemistry , microbiology and biotechnology , enzyme

Proinflammatory effects of SIRT1 inhibition exerts phase specific changes with decreased survival during hyper‐inflammation, and increased survival during hypo‐inflammation phases of sepsis.

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