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SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome
Author(s) -
Vachharajani Vidula T.,
Liu Tiefu,
Brown Candice M.,
Wang Xianfeng,
Buechler Nancy L.,
Wells Jonathan David,
Yoza Barbara K.,
McCall Charles E.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ma0114-034rr
Subject(s) - sepsis , biology , immunology , inflammation , ex vivo , nad+ kinase , spleen , proinflammatory cytokine , acute phase protein , systemic inflammation , cancer research , in vivo , biochemistry , microbiology and biotechnology , enzyme
Proinflammatory effects of SIRT1 inhibition exerts phase specific changes with decreased survival during hyper‐inflammation, and increased survival during hypo‐inflammation phases of sepsis.