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Human lung‐resident macrophages express CB 1 and CB 2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
Author(s) -
Staiano Rosaria I.,
Loffredo Stefania,
Borriello Francesco,
Iannotti Fabio Arturo,
Piscitelli Fabiana,
Orlando Pierangelo,
Secondo Agnese,
Granata Francescopaolo,
Lepore Maria Teresa,
Fiorelli Alfonso,
Varricchi Gilda,
Santini Mario,
Triggiani Massimo,
Di Marzo Vincenzo,
Marone Gianni
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi1214-584r
Subject(s) - endocannabinoid system , cannabinoid receptor , angiogenesis , biology , cannabinoid , receptor , vascular endothelial growth factor , microbiology and biotechnology , cancer research , agonist , biochemistry , vegf receptors
Activation of CBs on HLMs reduces production of lymph/angiogenic factors; a possible novel strategy to modulate macrophage‐assisted vascular remodeling.