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Impaired signaling through the Fms ‐like tyrosine kinase 3 receptor increases osteoclast formation and bone damage in arthritis
Author(s) -
Svensson Mattias N. D,
Erlandsson Malin C.,
Jonsson IngMarie,
Andersson Karin M. E,
Bokarewa Maria I.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi1114-572rr
Subject(s) - osteoclast , tyrosine kinase , receptor tyrosine kinase , arthritis , endocrinology , medicine , biology , cancer research , kinase , immunology , microbiology and biotechnology , signal transduction , receptor
Flt3L −/− is a negative regulator of OC differentiation by affecting expression of IRF8, and regulating the balance between T reg and Th17.