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Frontline Science: Shh production and Gli signaling is activated in vivo in lung, enhancing the Th2 response during a murine model of allergic asthma
Author(s) -
Standing Ariane S. I.,
Yánez Diana C.,
Ross Rosie,
Crompton Tessa,
Furmanski Anna L.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi1016-438rr
Subject(s) - biology , immunology , immune system , signal transduction , transcription factor , thymic stromal lymphopoietin , paracrine signalling , microbiology and biotechnology , receptor , genetics , gene
Hh/Gli signals are received by multiple pulmonary and immune cell types in response to allergen inhalation in vivo; this autocrine/paracrine activation enhances Th2 immune responses.