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Overexpression of progelatinase B/proMMP‐9 affects migration regulatory pathways and impairs chronic lymphocytic leukemia cell homing to bone marrow and spleen
Author(s) -
Bailón Elvira,
UgarteBerzal Estefanía,
AmigoJiménez Irene,
Van den Steen Philippe,
Opdenakker Ghislain,
GarcíaMarco José A.,
GarcíaPardo Angeles
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0913-521r
Subject(s) - homing (biology) , biology , transfection , cell migration , cancer research , bone marrow , rhoa , protein kinase b , small hairpin rna , chronic lymphocytic leukemia , spleen , small interfering rna , cell , microbiology and biotechnology , cell culture , leukemia , signal transduction , immunology , gene knockdown , ecology , genetics
Elevated (pro)MMP‐9 expression alters key regulatory molecules (ERK, FAK, RhoAGTPase, PTEN) and impairs CLL cell migration, favoring organ retention and disease progression.