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Frontline Science: Nasal epithelial GM‐CSF contributes to TLR5‐mediated modulation of airway dendritic cells and subsequent IgA response
Author(s) -
Cao Yuan,
Zhang Ejuan,
Yang Jingyi,
Yang Yi,
Yu Jie,
Xiao Yang,
Li Wei,
Zhou Dihan,
Li Yaoming,
Zhao Bali,
Yan Hu,
Lu Mengji,
Zhong Maohua,
Yan Huimin
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0816-368rr
Subject(s) - tlr5 , flagellin , cd86 , cd80 , biology , immunology , dendritic cell , antigen , toll like receptor , cytokine , immune system , tlr4 , tlr2 , in vitro , cd40 , t cell , receptor , innate immune system , cytotoxic t cell , biochemistry
Flagellin‐activated NECs secrete certain cytokines, particularly GM‐CSF, that convey the TLR5 signal of NECs to mucosal DCs, resulting in the subsequent IgA responses.