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Syk is involved in NLRP3 inflammasome‐mediated caspase‐1 activation through adaptor ASC phosphorylation and enhanced oligomerization
Author(s) -
Lin YingCing,
Huang DuenYi,
Wang JangShiun,
Lin YiLing,
Hsieh ShieLiang,
Huang KuoChin,
Lin WanWan
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0814-371rr
Subject(s) - syk , inflammasome , signal transducing adaptor protein , aim2 , microbiology and biotechnology , phosphorylation , caspase 1 , biology , kinase , effector , signal transduction , receptor , tyrosine kinase , biochemistry
Syk increases NLRP3 inflammasome formation through phosphorylation of ASC and enhancement of ASC oligomerization.