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Frontline Science: CXCR7 mediates CD14 + CD16 + monocyte transmigration across the blood brain barrier: a potential therapeutic target for NeuroAIDS
Author(s) -
Veenstra Mike,
Williams Dionna W.,
Calderon Tina M.,
Anastos Kathryn,
Morgello Susan,
Berman Joan W.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0517-167r
Subject(s) - cd16 , cd14 , biology , monocyte , blood–brain barrier , immunology , microbiology and biotechnology , neuroscience , central nervous system , flow cytometry , immune system , cd3 , cd8
CXCR7 is expressed on CD14 + CD16 + monocytes in PBMC from uninfected and HIV infected individuals; CCX771 specifically blocks CXCL12‐mediated transmigration of these cells.