Premium
A role for 12/15‐lipoxygenase‐derived proresolving mediators in postoperative ileus: protectin DX‐regulated neutrophil extravasation
Author(s) -
Stein Kathy,
Stoffels Melissa,
Lysson Mariola,
Schneiker Bianca,
Dewald Oliver,
Krönke Gerhard,
Kalff Jörg C.,
Wehner Sven
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0515-189r
Subject(s) - extravasation , biology , lipoxygenase , ileus , eicosanoid , arachidonate 5 lipoxygenase , immunology , medicine , endocrinology , arachidonic acid , enzyme , biochemistry
Resolution of POI involves monocytotic 12/15‐LOX activity and generation of PDX, resulting in reduction of neutrophil infiltration into the postoperative bowel wall.