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Frontline Science: Multiple cathepsins promote inflammasome‐independent, particle‐induced cell death during NLRP3‐dependent IL‐1β activation
Author(s) -
Orlowski Gregory M.,
Sharma Shruti,
Colbert Jeff D.,
Bogyo Matthew,
Robertson Stephanie A.,
Kataoka Hiroshi,
Chan Francis K.,
Rock Kenneth L.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3hi0316-152r
Subject(s) - inflammasome , cathepsin , pyroptosis , programmed cell death , cathepsin b , microbiology and biotechnology , biology , caspase 1 , proinflammatory cytokine , phagocytosis , secretion , nigericin , inflammation , apoptosis , immunology , biochemistry , membrane , enzyme
Multiple cathepsins promote particle‐induced cell death independently of inflammasomes, suggests that cathepsin inhibitors may therapeutically target multiple mechanisms of particle‐induced inflammatory disease.