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Metabolic danger signals, uric acid and ATP, mediate inflammatory cross‐talk between hepatocytes and immune cells in alcoholic liver disease
Author(s) -
Petrasek Jan,
IrachetaVellve Arvin,
Saha Banishree,
Satishchandran Abhishek,
Kodys Karen,
Fitzgerald Katherine A.,
KurtJones Evelyn A.,
Szabo Gyongyi
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ab1214-590r
Subject(s) - uric acid , inflammation , alcoholic liver disease , biology , immune system , proinflammatory cytokine , inflammasome , hepatocyte , medicine , endocrinology , endogeny , immunology , biochemistry , in vitro , cirrhosis
Uric acid and ATP from damaged hepatocytes activate IL‐1β, a signature inflammasome‐dependent cytokine crucial in the pathogenesis of alcoholic liver disease.