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Drug analog inhibition of indoleamine 2,3‐dioxygenase (IDO) activity modifies pattern recognition receptor expression and proinflammatory cytokine responses early during influenza virus infection
Author(s) -
Fox Julie M.,
Sage Leo K.,
Poore Spencer,
Johnson Scott,
Tompkins S. Mark,
Tripp Ralph A.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3ab0114-046rr
Subject(s) - proinflammatory cytokine , indoleamine 2,3 dioxygenase , immunology , immune system , biology , virus , cytokine , influenza a virus , interleukin 10 , virology , inflammation , tryptophan , biochemistry , amino acid
Inhibition of IDO activity with 1MT treatment following influenza infection enhances the production of IL‐6, TNF‐α, IL‐1β, and IFN‐β through modulation of macrophages.