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Staurosporine resistance in inflammatory neutrophils is associated with the inhibition of caspase‐ and proteasome‐mediated Mcl‐1 degradation
Author(s) -
Hornstein Tamara,
Lehmann Sarah,
Philipp Denise,
Detmer Susanne,
Hoffmann Michèle,
Peter Christoph,
Wesselborg Sebastian,
Unfried Klaus,
Windolf Joachim,
Flohé Sascha,
PaunelGörgülü Adnana
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a1114-537rr
Subject(s) - biology , staurosporine , myeloid leukemia , programmed cell death , apoptosis , intrinsic apoptosis , microbiology and biotechnology , leukemia , caspase , proteasome , cancer research , myeloid , immunology , kinase , protein kinase a , biochemistry
Triggering of Mcl‐1 degradation by Akt inhibition may overcome neutrophil intrinsic apoptosis resistance, and help reduce excessive inflammation in inflammatory diseases.