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Inhibition of lipopolysaccharide‐induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors
Author(s) -
Strålberg Fredrik,
Kassem Ali,
Kasprzykowski Franciszek,
Abrahamson Magnus,
Grubb Anders,
Lindholm Catharina,
Lerner Ulf H.
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a1016-433r
Subject(s) - in vivo , osteoclast , biology , in vitro , lipopolysaccharide , bone resorption , cysteine , resorption , cysteine proteinase inhibitors , microbiology and biotechnology , pharmacology , biochemistry , immunology , enzyme , endocrinology , apoptosis , caspase , programmed cell death
The inhibition of RANKL and LPS‐induced osteoclast formation by cysteine proteinase inhibitors demonstrate the role of cysteineproteinase(s) in physiological and pathological osteoclastogenesis.