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Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy‐independent mechanism
Author(s) -
He Li,
Weber Kassandra J.,
Diwan Abhinav,
Schilling Joel D.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a1015-463r
Subject(s) - autophagy , tfeb , pi3k/akt/mtor pathway , lysosome , microbiology and biotechnology , biology , lipotoxicity , mechanistic target of rapamycin , mitophagy , programmed cell death , mtorc1 , signal transduction , apoptosis , endocrinology , biochemistry , diabetes mellitus , insulin resistance , enzyme
Inhibition of mTOR kinase alters macrophage metabolism, and is protective against lipid toxicity in primary macrophages independent of autophagy.