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Systemic inflammatory response syndrome–related lymphopenia is associated with adenosine A 1 receptor dysfunction
Author(s) -
Riff Reut,
Cohen Yair,
EiniRider Hadar,
Naamani Oshri,
Mazar Julia,
Haviv Yosef S.,
Chaimovitz Cidio,
Douvdevani Amos
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0816-345rr
Subject(s) - adenosine , leukopenia , sepsis , biology , systemic inflammatory response syndrome , immunology , adenosine receptor , pharmacology , adenosine a1 receptor , medicine , endocrinology , receptor , toxicity , agonist
In SIRS, adenosine elevation desensitizes its Gi‐coupled A1 receptor, an effect associated to cAMP elevation and lymphopenia.