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N‐Octanoyl dopamine transiently inhibits T cell proliferation via G1 cell‐cycle arrest and inhibition of redox‐dependent transcription factors
Author(s) -
Wedel Johannes,
Hottenrott Maximillia C.,
Stamellou Eleni,
Breedijk Annette,
Tsagogiorgas Charalambos,
Hillebrands JanLuuk,
Yard Benito A.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0813-455r
Subject(s) - nod , cell growth , biology , il 2 receptor , t cell , ionomycin , cytokine , microbiology and biotechnology , nod mice , cd28 , intracellular , immunology , immune system , biochemistry , gene
N‐octanoyl dopamine displays transient T cell suppressive activity by preventing NFκB and AP‐1 activation, and acts synergistically with calcineurin inhibitors on T cell proliferation.