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T h 17 polarization of memory T h cells in early arthritis: the vasoactive intestinal peptide effect
Author(s) -
Jimeno Rebeca,
Leceta Javier,
Garín Marina,
Ortiz Ana M.,
Mellado Mario,
RodríguezFrade Jose Miguel,
Martínez Carmen,
PérezGarcía Selene,
Gomariz Rosa P.,
Juarranz Yasmina
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0714-327r
Subject(s) - vasoactive intestinal peptide , rar related orphan receptor gamma , foxp3 , interleukin 17 , biology , phenotype , immunology , interleukin 23 , endocrinology , medicine , cancer research , immune system , neuropeptide , receptor , gene , genetics
Th17 cells from eRA patients are prone to expand to a pathological cell population under Th17‐polarizing conditions where VIP prevents their pathogenesis.