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Adipose triglyceride lipase acts on neutrophil lipid droplets to regulate substrate availability for lipid mediator synthesis
Author(s) -
Schlager Stefanie,
Goeritzer Madeleine,
Jandl Katharina,
Frei Robert,
Vujic Nemanja,
Kolb Dagmar,
Strohmaier Heimo,
Dorow Juliane,
Eichmann Thomas O.,
Rosenberger Angelika,
Wölfler Albert,
Lass Achim,
Kershaw Erin E.,
Ceglarek Uta,
Dichlberger Andrea,
Heinemann Akos,
Kratky Dagmar
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0515-206r
Subject(s) - adipose triglyceride lipase , biology , lipid droplet , lipase , mediator , triglyceride , lipid signaling , substrate (aquarium) , lipid accumulation , adipose tissue , lipoprotein lipase , lipid metabolism , biochemistry , microbiology and biotechnology , enzyme , cholesterol , ecology
Lipid mediator release depends on the hydrolysis of triglyceride‐rich lipid droplets mediated by ATGL, a potent regulator of inflammatory diseases.