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Cytokine overproduction and crosslinker hypersensitivity are unlinked in Fanconi anemia macrophages
Author(s) -
Garbati Michael R.,
Hays Laura E.,
Rathbun R. Keaney,
Jillette Nathaniel,
Chin Kathy,
AlDhalimy Muhsen,
Agarwal Anupriya,
Newell Amy E. Hanlon,
Olson Susan B.,
Bagby Grover C.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0515-201r
Subject(s) - overproduction , biology , fanconi anemia , immunology , cytokine , delayed hypersensitivity , effector , antigen , genetics , gene , dna repair
TLR‐activated FANCC‐deficient macrophages overproduce inflammatory cytokines and sustain DNA damage, where induced DNA damage is not required to sustain aberrant cytokine responses.