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Rhesus macaque θ‐defensin RTD‐1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF‐κB and MAPK pathways
Author(s) -
Tongaonkar Prasad,
Trinh Katie K.,
Schaal Justin B.,
Tran Dat,
Gulko Percio S.,
Ouellette André J.,
Selsted Michael E.
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0315-102r
Subject(s) - biology , proinflammatory cytokine , mapk/erk pathway , protein kinase b , microbiology and biotechnology , phosphorylation , pi3k/akt/mtor pathway , kinase , iκbα , tumor necrosis factor alpha , p38 mitogen activated protein kinases , secretion , signal transduction , nf κb , inflammation , immunology , biochemistry
The anti‐inflammatory effects of θ‐defensin RTD‐1 are mediated by cell signaling pathways that down‐regulate expression of pro‐inflammatory cytokines.