Premium
Spleen‐derived IFN‐γ induces generation of PD‐L1 + ‐suppressive neutrophils during endotoxemia
Author(s) -
Langereis Jeroen D.,
Pickkers Peter,
Kleijn Stan,
Gerretsen Jelle,
Jonge Marien I.,
Kox Matthijs
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0217-051rr
Subject(s) - biology , spleen , immunology
Endotoxemia induces production of IFNγ locally in the spleen, which primes neutrophils to subsequently express the inhibitory checkpoint molecule PD‐L1, and suppress lymphocyte proliferation.