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Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli
Author(s) -
Qiu LianQun,
Lai Wi S.,
Bradbury Alyce,
Zeldin Darryl C.,
Blackshear Perry J.
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0214-106r
Subject(s) - proinflammatory cytokine , cxcl2 , biology , tristetraprolin , cxcl1 , microbiology and biotechnology , chemokine , tumor necrosis factor alpha , messenger rna , rna binding protein , fibroblast , immune system , inflammation , immunology , cell culture , gene , genetics , chemokine receptor
TTP‐promoted decay of transcripts is a critical post‐transcriptional regulatory mechanism in the response of fibroblasts to TNF released from primary immune cells.