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Trogocytic CD137 transfer causes an internalization of CD137 ligand on murine APCs leading to reduced T cell costimulation
Author(s) -
Shao Zhe,
Harfuddin Zulkarnain,
Pang Wan Lu,
Nickles Emily,
Koh Liang Kai,
Schwarz Herbert
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.3a0213-079rrr
Subject(s) - cd137 , internalization , microbiology and biotechnology , antigen presenting cell , immune system , adoptive cell transfer , biology , t cell , chemistry , cell , immunology , biochemistry
Trogocytic transfer of CD137 from T cells or tumor cells to antigen‐presenting cells leads to the internalization of CD137L and a reduced immune activity.