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Association of eukaryotic translation initiation factor eIF2B with fully solubilized CXCR4
Author(s) -
Palmesino Elena,
Apuzzo Tiziana,
Thelen Sylvia,
Mueller Bernd,
Langen Hanno,
Thelen Marcus
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ma0915-415r
Subject(s) - biology , microbiology and biotechnology , chemokine receptor , receptor , translation (biology) , cxcr4 , eukaryotic translation , internal ribosome entry site , chemokine , eukaryotic initiation factor , biochemistry , messenger rna , gene
Selective buffer conditions allow the solubilization of CXCR4 in near‐native conformation, and reveal specific agonist‐regulated interaction with eIF‐2B.