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Involvement of cell surface 90 kDa heat shock protein (HSP90) in pattern recognition by human monocyte‐derived macrophages
Author(s) -
Bzowska Małgorzata,
Nogieć Anna,
Bania Krystian,
Zygmunt Magdalena,
Zarębski Mirosław,
Dobrucki Jerzy,
Guzik Krzysztof
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ma0117-019r
Subject(s) - heat shock protein , biology , monocyte , microbiology and biotechnology , hsp70 , surface protein , hsp90 , macrophage , immunology , biochemistry , virology , in vitro , gene
HSP90 is constantly externalized on the surface of human macrophages; selective inhibition of this HSP90 pool suppresses the macrophages' response to PAMPs.