Premium
Interleukin‐3‐mediated regulation of β‐catenin in myeloid transformation and acute myeloid leukemia
Author(s) -
Sadras Teresa,
Perugini Michelle,
Kok Chung H.,
Iarossi Diana G.,
Heatley Susan L.,
Brumatti Gabriela,
Samuel Michael S.,
To Luen B.,
Lewis Ian D.,
Lopez Angel F.,
Ekert Paul G.,
Ramshaw Hayley S.,
DˈAndrea Richard J.
Publication year - 2014
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ab1013-559r
Subject(s) - myeloid leukemia , biology , wnt signaling pathway , catenin , cancer research , myeloid , chromosomal translocation , tcf4 , signal transduction , beta catenin , microbiology and biotechnology , gene , gene expression , promoter , genetics
IL‐3 activates β‐catenin in Hox‐transformed myeloid cells, and primary AML samples, presenting a novel axis for targeted inhibition of β‐catenin in some patients with AML.