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The E3 ubiquitin ligase RNF144B is LPS‐inducible in human, but not mouse, macrophages and promotes inducible IL‐1β expression
Author(s) -
Ariffin Juliana K.,
Kapetanovic Ronan,
Schaale Kolja,
GaticaAndrades Marcela,
Blumenthal Antje,
Schroder Kate,
Sweet Matthew J.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ab0815-339r
Subject(s) - biology , ubiquitin ligase , microbiology and biotechnology , lipopolysaccharide , gene expression , transcription factor , regulation of gene expression , gene silencing , innate immune system , promoter , gene , ubiquitin , immune system , immunology , genetics
LPS upregulates RNF144B in human macrophages for optimal IL‐1β expression and priming of inflammasome responses, but is not LPS‐inducible in mouse macrophages.