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AQP8 transports NOX2‐generated H 2 O 2 across the plasma membrane to promote signaling in B cells
Author(s) -
Bertolotti Milena,
Farinelli Giada,
Galli Mauro,
Aiuti Alessandro,
Sitia Roberto
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2ab0116-045r
Subject(s) - nadph oxidase , biology , microbiology and biotechnology , signal transduction , breakpoint cluster region , tyrosine phosphorylation , phosphorylation , protein tyrosine phosphatase , gene silencing , reactive oxygen species , biochemistry , receptor , gene
H2O2 produced by NOX2 is transported across the plasma membrane by AQP8 to promote B cell activation and differentiation.
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