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Up‐regulation of EP 2 and EP 3 receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE 2
Author(s) -
FlórezGrau Georgina,
Cabezón Raquel,
Borgman Kyra J. E.,
España Carolina,
Lozano Juan Jose,
GarciaParajo Maria F.,
BenítezRibas Daniel
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a1216-526r
Subject(s) - prostaglandin e2 receptor , receptor , microbiology and biotechnology , cd80 , biology , immune system , cd86 , dendritic cell , agonist , immune receptor , signal transduction , immunology , t cell , in vitro , cd40 , cytotoxic t cell , biochemistry
PGE 2 signals via EP 2 and EP 3 receptors to promote IL‐10 production by tol‐DCs, and potentiate their immunosuppressive properties.