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TLR8, but not TLR7, induces the priming of the NADPH oxidase activation in human neutrophils
Author(s) -
MakniMaalej Karama,
Marzaioli Viviana,
Boussetta Tarek,
Belambri Sahra Amel,
GougerotPocidalo MarieAnne,
HurtadoNedelec Margarita,
Dang Pham MyChan,
ElBenna Jamel
Publication year - 2015
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a1214-623r
Subject(s) - tlr7 , biology , nadph oxidase , phosphorylation , microbiology and biotechnology , priming (agriculture) , superoxide , agonist , signal transduction , receptor , reactive oxygen species , biochemistry , innate immune system , enzyme , toll like receptor , botany , germination
TLR‐8 primes PMN ROS by inducing the phosphorylation of p47phox and p38MAPKinase, while also involving Pin1.