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mTOR signaling disruption from myeloid‐derived suppressive cells protects against immune‐mediated hepatic injury through the HIF1α‐dependent glycolytic pathway
Author(s) -
Chen Xi,
Zhang Zhengguo,
Bi Yujing,
Fu Zan,
Gong Pingsheng,
Li Yan,
Yu Qing,
Jia Anna,
Wang Jian,
Xue Lixiang,
Yang Hui,
Liu Guangwei
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a1115-492r
Subject(s) - biology , pi3k/akt/mtor pathway , glycolysis , myeloid cells , microbiology and biotechnology , immune system , myeloid , signal transduction , cancer research , immunology , metabolism , biochemistry
mTOR negatively controls suppressive functions of MDSCs in immune‐mediated hepatic injury mouse models.