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Analysis of IgM antibody production and repertoire in a mouse model of Sjögren's syndrome
Author(s) -
Kramer Jill M.,
Holodick Nichol E.,
Vizconde Teresa C.,
Raman Indu,
Yan Mei,
Li QuanZhen,
Gaile Daniel P.,
Rothstein Thomas L.
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0715-297r
Subject(s) - biology , antibody , lymph node , spleen , immunology , lymph , autoantibody , salivary gland , b cell , submandibular gland , immune system , pathology , immunoglobulin g , immunoglobulin heavy chain , microbiology and biotechnology , medicine , endocrinology , biochemistry
IgM derived from salivary B cells exhibits distinct repertoire characteristics, and is enriched for specific autoantibodies in a murine model of SS.