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The effect of Rho drugs on mast cell activation and degranulation
Author(s) -
Sheshachalam Avinash,
Baier Alicia,
Eitzen Gary
Publication year - 2017
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0616-279rrr
Subject(s) - degranulation , rhoa , microbiology and biotechnology , biology , cytoskeleton , pseudopodia , mast cell , motility , cell , immunology , actin , signal transduction , receptor , biochemistry
Mast cell stimulation triggers the formation of a Rac GTPase‐activated actin‐rich degranulation zone, and a RhoA‐activated granule capture for exocytosis.