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Dual inhibition of histone deacetylases and phosphoinositide 3‐kinases: effects on Burkitt lymphoma cell growth and migration
Author(s) -
Ferreira Ana Carolina dos Santos,
deFreitasJunior Julio Cesar Madureira,
MorgadoDíaz Jose Andres,
Ridley Anne J.,
Klumb Claudete Esteves
Publication year - 2016
Publication title -
journal of leukocyte biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.819
H-Index - 191
eISSN - 1938-3673
pISSN - 0741-5400
DOI - 10.1189/jlb.2a0415-162r
Subject(s) - cancer research , histone deacetylase , biology , histone deacetylase inhibitor , pi3k/akt/mtor pathway , burkitt's lymphoma , lymphoma , immunology , histone , signal transduction , microbiology and biotechnology , biochemistry , gene
The HDACi/PI3Ki combination suppresses BL cell proliferation and migration through alterations in PI3K signaling and HDAC function.